Celecoxib is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib is used for the relief of acute pain and the pain of menstrual cramps. Before using this medication, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. Fluconazole increases the concentration of Celecoxib in the liver. If you are allergic to it or to sulfa drugs. Before using this medication, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain.