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Meanwhile, online pharmacies are offering discounts on Plavix, hoping the cheaper generic drug will maintain its market share. While you are taking Clopidogrel, do not take Plavix if you have ever had a stomach ulcer or bleeding in the area around the brain. Plavix, now the world's second best-selling drug, received FDA approval to thin the blood and prevent clots that can occur with certain heart or blood vessel conditions.